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Washington University Experience | NEURODEGENERATION | Progressive Supranuclear Palsy (PSP) | 14A0 Case 14 History
Case 14 History ---- The patient was a 70yo female who died in 11/2001 from complications of clinically defined progressive supranuclear palsy. Her illness began in 1992 with gait difficulties, and fecal incontinence. She had memory problems, had multiple daily falls, poor coordination, difficulty with feeding and dressing, and slurred speech. Exam in 1992 was notable for marked disorientation, decreased vertical gaze and slow horizontal smooth pursuits, decreased blinking and masked facies. There was spasticity on the right with right-sided weakness, bradykinesia worse on right, and marked postural instability with a short-stepped gait. Sensory exam was normal, and there was no dystonia, apraxia, cerebellar signs, or tremor. An MRI showed cortical and cerebellar atrophy. An LP showed moderate pleocytosis and markedly elevated protein. She had no benefit from Sinemet or other meds for Parkinson's Disease. Her disease progressed to include inability to ambulate, increased confusion, and speech difficulties.
