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Washington University Experience | NEURODEGENERATION | Progressive Supranuclear Palsy (PSP) | 1C1 PSP (Case 1) N1 PHF-1 14.jpg
1C1,2 Hyperphosphorylated ptau immunohistochemistry (PHF-1 IHC) shows numerous tau-immunoreactive highly branched ‘tufted’ astrocytes, abundant neuropil threads, many ‘coiled bodies and somewhat fewer tau-immunoreactive intraneuronal inclusions (globose and flame-shaped neurofibrillary tangles). (PHF1 IHC)