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Washington University Experience | NEURODEGENERATION | Progressive Supranuclear Palsy (PSP) | 4B4 PSP (Case 4) L14 H&E 40X dentate 100X 2
Hematoxylin and eosin stain reveals some loss of neurons and eosinophilic granular material (degenerating axon terminals) around degenerating neurons in the dentate nucleus ('grumose degeneration'). A few tau-immunoreactive neurofibrillary tangles and pre-tangles are seen in the dentate nucleus
