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Washington University Experience | PERIPHERAL NEUROPATHY | 1 NORMAL NERVE ANATOMY | 1 Normal H&E | 6A Normal sural nerve (Case 6) H&E 1

The endoneurial content of individual axons are better seen in this fascicle compared to the majority of biopsies because the myelin sheaths exhibit a neurokeratin or “wagon-wheel” artifact (arrow).. A typical formalin fixed paraffin embedded H&E-stained nerve provides a limited amount of information in the analysis of individual axons. (H&E)

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