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Washington University Experience | PRION DISEASES | Prion Diseases | 13D4 CJD (Case 13) 2 PrpImmuno
Immunohistochemical analyses using 3F4 monoclonal antibody raised against prion protein demonstrate granular deposits of prion protein involving both molecular and granule cell layers. (3F4 IHC) ---- The diagnosis of CJD is supported by the NPDPSC findings of immunoblot demonstration of abnormal protease resistant prion protein (PrP 27-30), 3F4 immunohistochemistry and PrPSc gene sequencing (the patient does not have a familial form).
