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Washington University Experience | PRION DISEASES | Prion Diseases | 14E CJD (Case 14) cortex H&E 1

Sections of frontal and parietal lobes and affecting all cortical layers, are homogeneously distributed small vacuoles, which vary in size and involve the neuropil. There is also neuronal loss accompanied by astrocytosis. There is no evidence of significant numbers of neurofibrillary tangles, Pick bodies or ballooned cells. The appearance of underlying deeper white matter shows mild focal pallor and increased numbers of astrocytes. ---- The immunoblot performed at the NPDPSC reveals abnormal protease resistant prion protein commonly identified as PrP 27-30 confirming the diagnosis of Creutzfeldt-Jakob disease.

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