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Washington University Experience | PRION DISEASES | Prion Diseases | 20A2 CJD (Case 20) N5 H&E 10X (scale)
Sections of the grey matter in the cerebral hemispheres, basal ganglion, thalamus and molecular layer of the cerebellum show spongiform encephalopathy. In these regions there is vacuolation of the neuropil and occasional intra-neuronal vacuoles. The vacuoles are round and regular and range in size from approximately 5-25 um in diameter. Also, there is marked neuron loss and focally severe gliosis.
