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Washington University Experience | PRION DISEASES | Prion Diseases | 21A1 CJD (Case 21) diffusion-trace slice 35 - Copy
Case 21 History ---- The patient was a 59-year old woman who presented approximately 10 months prior to her death with significant cognitive impairment, loss of appetite, loss of interest in usual activities, and left-sided "buzzing" tinnitus. MR imaging performed June 2014 showed gyriform cortical diffusion restriction predominantly involving regions of the default mode network and also seen in the striatum and medial thalamus, left greater than right. In the setting of rapidly progressive dementia, the findings were most consistent with sporadic Creutzfeldt-Jakob disease. The patient was placed in hospice care with symptoms of impulsiveness, treated with Seroquel. She was desaturating into the 80s just prior to her death in mid October 2014. ---- At autopsy the weight of the unfixed brain is 1100g. The external surface of the brain was unremarkable. ---- 21A1 This diffusion weighted slice shows patchy hyperintensity of the cortex and the caudate nuclei.
