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Washington University Experience | PRION DISEASES | Prion Diseases | 22B1 CJD (Case 22) H&E A WM
22B1,2 Coronal sections through the cerebral hemispheres confirm the presence of gyral narrowing and widening of the sulci in the areas described above. Hematoxylin and eosin stained sections of the cerebrum show diffuse cortical spongiform changes with variable vacuolar size and some degree of coalescence, as well as neuronal loss and gliosis. The changes are most pronounced in the occipital lobe and hippocampus as compared to the frontal and temporal lobes and thalamus. Considering the atrophy in this brain, an attempt was made to identify Alzheimer-type neuropathology or cortical Lewy bodies which were not compelling for an additional diagnosis.
