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Washington University Experience | PRION DISEASES | Prion Diseases | 22C2 CJD (Case 22) H&E O H&E 10X (scale bar)
Purkinje and granular cell loss were prominent in all sections. Spongiform changes extended through all cortical layers into the underlying white matter. Bergmann gliosis and fibrillary gliosis in the granular layer was present. Loss of white matter fibers was prominent. ---- Diagnosis: Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease).The NPDPSC reported immunoreactive 3F4 granular deposits as seen in prion disease (establishes the diagnosis of prion disease likely Creutzfeldt-Jakob disease. The immunoblot reveals the presence of abnormal protease resistant prion protein (PrPSc) commonly identified as PrP 27-30 confirming the diagnosis of prion disease based on the current criteria. This was subtyped as MM 2C. There were no other pathological processes identified.
