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Washington University Experience | PRION DISEASES | Prion Diseases | 4C1 CJD, 5 yr Hx PrP proven (Case 4) whole mount 2

4C1-4 There are progressively increased magnifications of this cerebral cortex. There are severe loss of neurons, in places including the full depth of the cortical ribbon, status spongiosus (expanded extracellular spaces resulting from neuron loss and astrocytosis), and gliosis throughout the neocortex. There are no beta-amyloid plaques, no neuritic plaques, and no neurofibrillary tangles. Ubiquitin- and TDP-43-immunoreactive neuronal cytoplasmic inclusions (NCIs) and Lewy bodies are also not present.

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