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Washington University Experience | PRION DISEASES | Prion Diseases | 4C2 CJD, 5 yr Hx PrP proven (Case 4) H&E 6

There are progressively increased magnifications of this cerebral cortex. There are severe loss of neurons, in places including the full depth of the cortical ribbon, status spongiosus (expanded extracellular spaces resulting from neuron loss and astrocytosis), and gliosis throughout the neocortex.

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