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Washington University Experience | PRION DISEASES | Prion Diseases | 9B2 CJD, with kuru plaques (Case 9) H&E 7.jpg
9B2-6 Additionally, the cerebellum shows widespread kuru plaques that are found in the Purkinje cell, molecular, and granular cell layers. These cerebellar plaques are negative for beta-amyloid and TDP-43 by immunohistochemical staining. TDP-43 staining is also negative in the hippocampal region. The blood vessels essentially lack amyloid deposition.
