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Washington University Experience | PRION DISEASES | Prion Diseases | 9C3 Axon, spheroids, Torpedo (CJD, different case)
A torpedo from another CJD case showing its axonal origin from a Purkinje cell. ---- Comment: The major findings in this case include widespread spongiform changes, consistent with sporadic Creutzfeldt- Jakob disease (sCJD). This is supported by the NPDPSC findings of immunoblot demonstration of abnormal protease resistant prion protein (PrP27-30), 3F4 immunohistochemistry and PrP gene sequencing (the patient does not have a familial form). Overlapping with the changes of sCJD, there are severe and extensive Alzheimer's disease-like changes. Histologically, the evidence for Alzheimer's disease-like changes include extensive beta-amyloid deposition and scattered neurofibrillary tangles seen in the frontal cortex, hippocampal, and parahippocampal regions. TDP-43 staining was negative in these regions.
