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Washington University Experience | VASCULAR | Congophilic Angiopathy (CAA) | 10A0 Case 10 History
Case 10 History ---- At age 75 years, this patient presented with a family history of Alzheimer disease. Her health history included cerebrovascular disease with a possible prior stroke (year unknown), thyroid dysfunction, colitis, frequent falls, depression, and dementia of the Alzheimer type (DAT). At her first visit, a collateral source reported a six-year history of memory and thinking deterioration of gradual onset and progression over the past three to four years. The examiner rated the patient a CDR 1 with a diagnosis of DAT. She remained socially appropriate. She was found unresponsive in her room at the assisted living complex and was admitted to a nearby hospital where she was diagnosed with a massive cerebral hemorrhage. She remained unresponsive until her death two days later. Her nephew and assisted living staff reported that she had had more than 9 TIAs within a few weeks during the last months of her life. Her CDR at time of death was 2. In summary, this P had a 7-8 year history of cognitive decline, including memory loss, disorientation, and confusion. She died of a massive intracerebral bleed. ---- At the time of autopsy her unfixed brain weighed 1,250 g with neuropathological change consistent with a diagnosis of AD (NIA-AA rating was A3B3C3, highly likely her dementia resulted from DAT).
