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Washington University Experience | VASCULAR | Congophilic Angiopathy (CAA) | 14A0 Case 14 History
Case 14 History ---- This 66-year-old woman had a strong family history of Alzheimer disease with late onset. Her medical history was significant for ASHD, CABG in 1983, hypercholesterolemia, hypertension, angioplasty, and stent placement. The clinician rated her CDR 0, no dementia, at her initial visit. Because of a strong family history of dementia, she was quite concerned about memory problems and was taking Aricept and Namenda. At that time CDR was 0.5. ---- At her 6 year assessment, her daughter noted consistent memory problems that had gradually worsened over time. She died suddenly of a cardiac arrest on 3/15 at age 75, eight years into the clinical course of her dementia. ---- Autopsy revealed a fresh (unfixed) brain which weighed 1085 g. She received a diagnosis of Alzheimer disease with secondary diagnoses of arteriolosclerosis, severe CAA as well as moderate atherosclerosis. A neuropathological diagnosis of AD was made by Khachaturian criteria, are consistent with 'definite' AD by CERAD criteria, and they indicate a 'high' probability that the patient’s cognitive changes are due to AD by NIA-Reagan Institute criteria.
