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Washington University Experience | VASCULAR | Congophilic Angiopathy (CAA) | 19A0 Case 19 History
Case 19 History ---- This 68-year-old man had a sister and daughter (onset 49yo) with DAT and a health history of coronary artery disease and hypertension. In September 2007, he had a 5-minute episode of tingling and numbness in his right hand and tongue in addition to slurred speech. He was worked up for possible TIA, including a brain CT, which was negative. His neurologic exam was unremarkable and he was rated CDR 0, no dementia. In July 2010 he had a myocardial infarction followed by stent placement. He was taking Plavix and aspirin. He awakened during the night to use the bathroom and fell. He was transported to the ER where a head CT revealed a large left frontotemporal intra-parenchymal hemorrhage with midline shift. He died later that day at age 69. There was no clinical evidence of a progressive neurodegenerative disease. ---- At autopsy his brain was edematous and weighed 1500 grams. He had a recent hemorrhage, intraparenchymal and subarachnoid in the left frontoparietal lobes, accompanied by congophilic angiopathy, with slight Alzheimer's type neuropathologic changes.
