Table of Contents
Washington University Experience | VASCULAR | Congophilic Angiopathy (CAA) | 24A0 Case 24 History
Case 24 History ---- The patient was a 71 year old hypertensive man whose neurologic history is notable for having had three hemorrhagic strokes in the past including a left parieto-occipital intracerebral hemorrhage. Since that time he had mild cognitive impairment with probably some memory difficulty as well. He subsequently had at least two further hemorrhages, one in 1997 which may have been left frontal and then another parieto-occipital hemorrhage in late May of 1999. He was noted to have developed greater aphasia and more difficulty understanding and seeing. Also at that time his aphasia and other problems became significant enough that he was admitted to a nursing home. Because the locations of his intracerebral hemorrhages had all been cortical, he was given a tentative diagnosis of cerebral amyloid angiopathy since there was no evidence of vascular malformation or other abnormality to account for the hemorrhages. ---- At autopsy the weight of the unfixed brain was 1550 g. He received diagnoses of Alzheimer disease, congophilic angiopathy with multiple cerebral hemorrhages involving all lobes of the right and left cerebral hemispheres. He also had multiple remote/resolving cerebral hemorrhagic infarcts, involving the left frontal, occipital, temporal and parietal lobes and amygdala.
