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Washington University Experience | VASCULAR | Congophilic Angiopathy (CAA) | 2A0 Case 2 History
Case 2 History ---- This 71-year-old woman had a family history of dementia including her mother with age of onset of 63 and two sisters. Her PMHx was significant for hypertension, possible TIAs, lifelong depression and a 3-4 year history of forgetting recent events, repeating, and misplacing items which started slowly and was progressive. She developed personality changes of agitation and being short-tempered, and had difficulty with time relationships. Her judgment and problem-solving skills were reported as very poor. She had been living in a nursing home since for the last two years of her life. She did poorly on the MAP testing and was rated CDR (Clinical Dementia Rating) 2, DAT (Dementia of the Alzheimer Type) with cerebrovascular disease thought not contributing importantly to her dementia. She died at age 71 of inanition at a time when she required total care (CDR 3). ---- At autopsy her unfixed brain weight was 1,200 g. Alzheimer disease was present using Khachaturian, CERAD and NIA-Reagan criteria and she had both arteriolosclerosis and CAA, focally severe. Microinfarcts were remote/subacute in medial temporal and parietal lobes, amygdala, caudate and cerebellum.
