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Washington University Experience | VASCULAR | Congophilic Angiopathy (CAA) | 8A0 Case 8 History
Case 8 History ---- This patient had a strong family history of dementia of the Alzheimer type (DAT) and was beginning to show signs of disease himself at 69 years of age. She reported some trouble with recent memory that was intermittent and not severe. She was rated CDR 0.5 uncertain dementia. At 70 her short term memory had worsened but her long term memory recall was much better. At 75 she was unable to recall events, even from two to three days prior. She was misplacing objects, had trouble finding words in conversation, forgot appointments, repeated questions and lost track of the days. She became completely dependent for all of her care and was mute (last 2-3 years). She died shortly thereafter with a 14 year history of gradual decline in memory and thinking that lead to her total dependence for all of her care prior to her death at age 83. ---- Autopsy revealed a 900 gram unfixed, fresh brain with Alzheimer disease (NIA-AA rating A3B3C2 – high likelihood that DAT accounted for her dementia) as well as arteriolosclerosis, severe CAA, a remote basal ganglia hemorrhage and moderate atherosclerosis.
