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Washington University Experience | VASCULAR | Hypoxia-Ischemia, fetal-neonatal | White Matter | 11A0 Case 11 History
Case 11 History ---- The patient was a male infant born to a 19 year old G1 mother at 39 weeks gestation. The pregnancy was uncomplicated. Labor began 36 hours prior to delivery. The membranes ruptured spontaneously about six hours prior to delivery yielding meconium stained fluid. The child was delivered vaginally from a frank breech presentation. He was in severe distress at birth with Apgars of two at one minute and 5 at five minutes. The child was aggressively resuscitated and transferred to SLCH. The child suffered from severe hypotension and hypoxia and expired at one day of age despite vigorous therapy. The infant had a normal male karyotype, 46XY. ---- At autopsy there was bilateral renal agenesis and "Potter's facies". The child had intractable respiratory distress and died soon after birth. Thus pulmonary hypoplasia is often the most clinically significant aspect of the renal agenesis complex. The presence of mineralized neurons and axons resembling periventricular leukomalacia at the time of death at one day of age, are consistent with an intrauterine event. There was no evidence of an intrauterine infection.
